Ros-mediated activation of NF-kappaB and Foxo during muscle disuse

Muscle Nerve. 2010 Jan;41(1):110-3. doi: 10.1002/mus.21526.


We examined reactive oxygen species as upstream activators of nuclear factor kappaB; (NF-kappaB) and forkhead box O (Foxo) in skeletal muscle during disuse atrophy. Catalase, an enzyme that degrades H2O2, was overexpressed in soleus muscles via plasmid injection prior to 7 days of hindlimb immobilization. The increased catalase activity abolished immobilization-induced transactivation of both NF-kappaB and Foxo and attenuated the loss of muscle mass. Thus, H2O2 may be an important initiator of these signaling pathways that lead to muscle atrophy.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Blotting, Western
  • Cell Line
  • Disease Models, Animal
  • Enzyme Activation / physiology*
  • Follow-Up Studies
  • Forkhead Transcription Factors / drug effects
  • Forkhead Transcription Factors / metabolism*
  • Male
  • Muscle, Skeletal / metabolism*
  • Muscle, Skeletal / pathology
  • Muscular Disorders, Atrophic / metabolism*
  • Muscular Disorders, Atrophic / pathology
  • NF-kappa B / drug effects
  • NF-kappa B / metabolism*
  • Rats
  • Rats, Sprague-Dawley
  • Reactive Oxygen Species / pharmacology*
  • Signal Transduction


  • Forkhead Transcription Factors
  • NF-kappa B
  • Reactive Oxygen Species