NMDA receptor antagonists reduce medial, but not lateral, perforant path-evoked EPSPs in dentate gyrus of rat hippocampal slice

Exp Brain Res. 1990;83(1):172-7. doi: 10.1007/BF00232206.


NMDA receptor antagonists produced differential effects on medial and lateral perforant path-evoked excitatory postsynaptic potentials (EPSPs) recorded in the dentate gyrus molecular layer of hippocampal slices. D-(-)-2-amino-5-phosphonovaleric acid (D(-)-APV) and 3[(+/-)-2-carboxypiperazin-4-yl]-propyl-1-phosphonic acid (CPP) significantly reduced the peak amplitude and total area, but not the initial negative slope, of the medial perforant path-evoked EPSP. Neither antagonist affected any component of the lateral perforant path-evoked EPSP. In contrast, population spikes evoked by stimulation of either pathway were depressed.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 2-Amino-5-phosphonovalerate / pharmacology*
  • Animals
  • Hippocampus / physiology*
  • Male
  • Membrane Potentials / drug effects
  • Membrane Potentials / physiology*
  • Neuromuscular Junction / drug effects
  • Neuromuscular Junction / physiology
  • Organophosphorus Compounds / pharmacology*
  • Piperazines / pharmacology*
  • Rats
  • Rats, Inbred Strains
  • Receptors, N-Methyl-D-Aspartate / physiology
  • Synapses / drug effects
  • Synapses / physiology*


  • Organophosphorus Compounds
  • Piperazines
  • Receptors, N-Methyl-D-Aspartate
  • SDZ EAA 494
  • 2-Amino-5-phosphonovalerate