Role of extracellular adenosine in acute lung injury

Physiology (Bethesda). 2009 Oct:24:298-306. doi: 10.1152/physiol.00022.2009.


Acute lung injury (ALI) is a lung disease characterized by pulmonary edema and severe hypoxia. The past decade hosted a search for endogenous mechanisms controlling lung inflammation and pulmonary edema during ALI. As such, recent evidence indicates extracellular adenosine in orchestrating the resolution of pulmonary edema and inflammation during ALI.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenosine / physiology*
  • Animals
  • Capillaries / physiology
  • Extracellular Space / physiology*
  • Humans
  • Lung Diseases / pathology*
  • Nucleotides / metabolism
  • Pulmonary Alveoli / physiology
  • Receptor, Adenosine A2A / physiology
  • Receptor, Adenosine A2B / physiology


  • Nucleotides
  • Receptor, Adenosine A2A
  • Receptor, Adenosine A2B
  • Adenosine