Final height of adults with childhood-onset steroid-responsive idiopathic nephrotic syndrome

Pediatr Nephrol. 2009 Dec;24(12):2401-8. doi: 10.1007/s00467-009-1301-z.


The aim of this study was to evaluate the final stature of adults with childhood-onset steroid-responsive idiopathic nephrotic syndrome (INS) and the influence of disease-related issues on the achievement of their target heights. We analyzed 60 (41 male) patients and/or their records, with a minimum age of 19 years or at a Tanner's pubertal stage 4 for boys or status postmenarche for girls, and normal glomerular filtration rate. Mean age at first and last consultation was 5.3+/-2.4 years and 20.5+/-3.1 years, respectively. Mean follow-up period was 15.10 years. Mean cumulative dose of prednisone was 1254+/-831.40 mg/kg. Mean initial and final height Z scores (HtZ) were, respectively, -0.60+/-1.0 and -0.64+/-0.92 (p=0.72). The final HtZ showed a significant correlation only with the initial HtZ and the target HtZ (THZ). Six patients achieved a final HtZ below -2, which in male patients correlated strongly to the initial HtZ and THZ. A strong correlation was demonstrated between final HtZ, initial HtZ, and THZ. INS-related issues did not prevent the final stature to reach the predicted target height.

MeSH terms

  • Body Height / drug effects*
  • Child
  • Child Development / drug effects*
  • Child, Preschool
  • Chlorambucil / therapeutic use
  • Cyclophosphamide / therapeutic use
  • Cyclosporine / therapeutic use
  • Drug Therapy, Combination
  • Female
  • Follow-Up Studies
  • Glucocorticoids / therapeutic use*
  • Growth Disorders / drug therapy*
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Longitudinal Studies
  • Male
  • Nephrotic Syndrome / drug therapy*
  • Nephrotic Syndrome / pathology
  • Prednisone / therapeutic use
  • Retrospective Studies
  • Sex Factors
  • Time Factors
  • Young Adult


  • Glucocorticoids
  • Immunosuppressive Agents
  • Chlorambucil
  • Cyclosporine
  • Cyclophosphamide
  • Prednisone