Temporal production of the two Bacillus anthracis siderophores, petrobactin and bacillibactin
- PMID: 19816776
- PMCID: PMC3057204
- DOI: 10.1007/s10534-009-9272-x
Temporal production of the two Bacillus anthracis siderophores, petrobactin and bacillibactin
Abstract
Bacillus anthracis secretes two siderophores, petrobactin (PB) and bacillibactin (BB). These siderophores were temporally produced during germination and outgrowth of spores (the usual infectious form of B. anthracis) in low-iron medium. The siderophore PB was made first while BB secretion began several hours later. Spore outgrowth early in an infection may require PB, whereas delayed BB production suggests a role for BB in the later stages of the infection. Incubation of cultures (inoculated as vegetative cells) at 37 degrees C, as compared to 2 degrees C, increased PB production and decreased secretion of BB, suggesting that the production of PB and BB responded to the host temperature signal. The dual siderophores of B. anthracis may fulfill independent roles in the life cycle of B. anthracis.
Figures
References
-
- Abergel RJ, Zawadzka AM, Raymond KN. Petrobactin-mediated iron transport in pathogenic bacteria. J Am Chem Soc. 2008;130:2124–2125. - PubMed
-
- Bergeron RJ, Huang GF, Smith RE, Bharti N, McManis JS, Butler A Total synthesis and structure revision of petrobactin. Tetrahedron. 2004;59:2007–2014.
-
- Byers BR, Arceneaux JEL. Metal Ions in Biological Systems. Vol. 35. M. Dekker; New York: 1998. Microbial iron transport: iron acquisition by in microorganisms, plants, and animals; pp. 37–66. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
