Primary extranodal marginal zone lymphoma of the uvea associated with massive diffuse epibulbar extension and focal infiltration of the optic nerve and meninges, clinically presented as uveitis masquerade syndrome: a case report

Med Oncol. 2010 Sep;27(3):1010-6. doi: 10.1007/s12032-009-9325-6. Epub 2009 Oct 9.

Abstract

To report a clinical, histopathological and immunohistochemical findings in a case of primary extranodal marginal zone lymphoma of the uvea associated with massive diffuse extraocular episcleral extension and focal infiltration of the optic nerve and meninges, clinically presented as longstanding uveitis masquerade syndrome. Interventional case reports with histopathological correlation. We describe a 80-year-old male patient with a 3-year history of chronic recurrent hypertensive (pan) uveitis associated with ocular pain, unresponsive to topical and systemic anti-inflammatory, immunosuppressive, antibiotic/antiviral and antiglaucomatous therapy. Because the eye was not salvageable with conservative treatment, enucleation of blind and painful eye was performed. Findings from histopathological and immunohistochemistry examination of the enucleated eye showed an extranodal marginal zone lymphoma of the uveal tract with massive epibulbar extension and optic nerve and meningeal penetration. During almost 3 years of clinical course and 6 months after the enucleation, there were no systemic manifestations of lymphoma, and patient has not required subsequent treatment. Primary lymphoproliferative lesions of the uvea, comprising the iris, ciliary body and choroid are very rare, associated with epibulbar extension extremely and with optic nerve and menigeal penetration exceptionally. Despite its rarity, primary lymphoma of the uvea should be included in the differential diagnosis particularly in older patients with longstanding recurrent uveitis.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Biopsy, Needle
  • Diagnosis, Differential
  • Diagnostic Errors*
  • Eye Enucleation
  • Glaucoma, Neovascular / etiology
  • Glaucoma, Neovascular / surgery
  • Humans
  • Lymphoma, B-Cell, Marginal Zone / complications
  • Lymphoma, B-Cell, Marginal Zone / diagnosis*
  • Lymphoma, B-Cell, Marginal Zone / pathology
  • Lymphoma, B-Cell, Marginal Zone / surgery
  • Male
  • Meninges / pathology*
  • Neoplasm Invasiveness
  • Optic Nerve / pathology*
  • Recurrence
  • Remission Induction
  • Retinal Detachment / etiology
  • Uveal Neoplasms / complications
  • Uveal Neoplasms / diagnosis*
  • Uveal Neoplasms / pathology
  • Uveal Neoplasms / surgery
  • Uveitis, Anterior / diagnosis*