Statins as anti-arrhythmics: a systematic review part II: effects on risk of ventricular arrhythmias

Clin Cardiol. 2009 Oct;32(10):549-52. doi: 10.1002/clc.20435.


Background: Recent studies have demonstrated that statins may possess anti-arrhythmic properties in addition to their lipid-lowering effects.

Methods: Studies which reported the association of statins with the incidence of ventricular arrhythmias were identified through a systematic review of the published literature.

Results: Statins have been associated with a significant reductions in ventricular arrhythmia in cardiomyopathy patients with an implantable cardioverter defibrillator, although randomized trials have not been completed.

Conclusions: Published data suggests that statins may possess anti-arrhythmic properties that reduce the propensity for ventricular arrhythmias. Most of this data is observational; more randomized, placebo-controlled trials are needed.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Anti-Arrhythmia Agents / therapeutic use*
  • Arrhythmias, Cardiac / etiology
  • Arrhythmias, Cardiac / prevention & control*
  • Combined Modality Therapy
  • Death, Sudden, Cardiac / etiology
  • Death, Sudden, Cardiac / prevention & control
  • Defibrillators, Implantable*
  • Evidence-Based Medicine
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
  • Risk Factors
  • Secondary Prevention
  • Treatment Outcome


  • Anti-Arrhythmia Agents
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors