Estimating treatment effects of longitudinal designs using regression models on propensity scores

Biometrics. 2010 Sep;66(3):824-33. doi: 10.1111/j.1541-0420.2009.01334.x.


We derive regression estimators that can compare longitudinal treatments using only the longitudinal propensity scores as regressors. These estimators, which assume knowledge of the variables used in the treatment assignment, are important for reducing the large dimension of covariates for two reasons. First, if the regression models on the longitudinal propensity scores are correct, then our estimators share advantages of correctly specified model-based estimators, a benefit not shared by estimators based on weights alone. Second, if the models are incorrect, the misspecification can be more easily limited through model checking than with models based on the full covariates. Thus, our estimators can also be better when used in place of the regression on the full covariates. We use our methods to compare longitudinal treatments for type II diabetes mellitus.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Diabetes Mellitus
  • Humans
  • Longitudinal Studies
  • Models, Statistical
  • Propensity Score*
  • Regression Analysis
  • Treatment Outcome*