Effect of konjac glucomannan hydrolysates and probiotics on the growth of the skin bacterium Propionibacterium acnes in vitro

Int J Cosmet Sci. 2010 Apr;32(2):139-42. doi: 10.1111/j.1468-2494.2009.00555.x. Epub 2009 Oct 10.


The synbiotic ability of probiotic bacteria and konjac glucomannan hydrolysates (GMH) to inhibit acne-inducing bacterium, Propionibacterium acnes growth was studied in vitro. All probiotic bacteria strains tested were able to inhibit the growth of this species of skin bacterium where the inhibition was significantly (P < 0.01) enhanced by the presence of the GMH prebiotic. As the current treatment of acne is based on topical or systemic drugs, it is worth examining further the biotherapeutic activities of the GMH and selected probiotics with a view to future use as prophylactic or therapeutic synbiotics for treating acne infections.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acne Vulgaris / microbiology*
  • Colony Count, Microbial
  • Humans
  • Lactobacillus / physiology*
  • Mannans / pharmacology*
  • Probiotics / pharmacology*
  • Propionibacterium acnes / drug effects*
  • Propionibacterium acnes / growth & development*


  • Mannans
  • (1-6)-alpha-glucomannan