Clin Liver Dis. 2009 Nov;13(4):631-47. doi: 10.1016/j.cld.2009.07.007.


Primary liver cancer is the fifth most common malignancy worldwide and the third leading cause of cancer mortality. Non-alcoholic fatty liver disease is the most common cause of chronic liver disease in the United States encompassing a spectrum of entities marked by hepatic steatosis in the absence of significant alcohol consumption. Although simple steatosis follows a generally benign course, the more aggressive form, non-alcoholic steatohepatitis, can progress to cirrhosis and result in complications including hepatocellular carcinoma. A significant number of cases of hepatocellular carcinoma remain cryptogenic without known underlying chronic liver disease. It is increasingly recognized that non-alcoholic steatohepatitis likely accounts for a substantial portion of cryptogenic hepatocellular carcinoma.

MeSH terms

  • Carcinoma, Hepatocellular / diagnosis
  • Carcinoma, Hepatocellular / epidemiology
  • Carcinoma, Hepatocellular / etiology*
  • Fatty Liver / complications*
  • Fatty Liver / pathology
  • Hepatitis C, Chronic / complications
  • Hepatitis C, Chronic / epidemiology
  • Humans
  • Incidence
  • Liver Cirrhosis / etiology
  • Liver Cirrhosis / virology
  • Liver Neoplasms / diagnosis
  • Liver Neoplasms / epidemiology*
  • Liver Neoplasms / etiology*
  • Prevalence
  • Prognosis
  • Risk Factors
  • United States / epidemiology