Imidazopyridine-5,6,7,8-tetrahydro-8-quinolinamine derivatives with potent activity against HIV-1

Bioorg Med Chem Lett. 2009 Nov 15;19(22):6399-403. doi: 10.1016/j.bmcl.2009.09.056. Epub 2009 Sep 19.


Synthesis of several novel imidazopyridine-5,6,7,8-tetrahydro-8-quinolinamine derivatives with potent activity against HIV are described. Synthetic approaches allowing for variation of the substitution pattern are outlined and resulting changes in antiviral activity and pharmacokinetics are highlighted. Several compounds with low nanomolar anti-HIV activity and oral bioavailability are described.

MeSH terms

  • Anti-HIV Agents / pharmacokinetics
  • Anti-HIV Agents / therapeutic use
  • Antiviral Agents / pharmacology
  • Antiviral Agents / therapeutic use*
  • Cell Line, Tumor
  • HIV / chemistry
  • HIV Infections / drug therapy
  • HIV-1 / drug effects
  • Humans
  • Models, Chemical


  • Anti-HIV Agents
  • Antiviral Agents