MicroRNA 125a and its regulation of the p53 tumor suppressor gene

FEBS Lett. 2009 Nov 19;583(22):3725-30. doi: 10.1016/j.febslet.2009.10.002. Epub 2009 Oct 8.


MicroRNA (miRNA) are a class of non-coding RNA that suppress gene expression by degradation or translational inhibition of target RNA. Several miRNA have been shown to target oncogenes and recently miRNA-125b was shown to translationally and transcriptionally inhibit the p53 gene. Here, we show that an additional isomer of miRNA-125 (miRNA-125a) translationally arrests mRNA of the p53 tumor suppressor gene. The basis of this activity is the high degree of sequence homology between the seed sequence of miR-125a and the 3'-UTR of p53. Our findings add miRNA-125a to the growing list of miRNA with oncogenic targets.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • 3' Untranslated Regions / genetics
  • Blotting, Northern
  • Blotting, Western
  • Cell Line
  • Cell Line, Tumor
  • Cell Proliferation
  • Cell Survival
  • Gene Expression Regulation*
  • Humans
  • MicroRNAs / genetics*
  • Protein Biosynthesis
  • RNA Interference
  • Reverse Transcriptase Polymerase Chain Reaction
  • Transfection
  • Tumor Suppressor Protein p53 / genetics*
  • Tumor Suppressor Protein p53 / metabolism


  • 3' Untranslated Regions
  • MIRN125 microRNA, human
  • MicroRNAs
  • Tumor Suppressor Protein p53