Age-related relative volume preservation of the dominant hand cortical region

Brain Res. 2009 Dec 11;1305:14-9. doi: 10.1016/j.brainres.2009.10.001. Epub 2009 Oct 9.

Abstract

Aging is usually associated with a progressive difficulty in learning new skills. Similarly, the dexterity in the non-dominant hand is usually decreased with age, while the dominant hand maintains a relative preservation in agility. We investigated if age-related volume loss affects the hand areas asymmetrically by comparing structural measures of the dominant hand area versus the non-dominant area. We performed a region of interest analysis of T1-weighted images focusing on the sensorimotor cortex corresponding to the hand area. We evaluated images from young subjects (younger than 65 years of age, n=38, mean age=24+/-7 years) and senior subjects (65 years or older, n=61, mean age =73+/-6 years). We observed that older adults exhibited greater leftward gray matter asymmetry of sensorimotor cortex, due in large part to more pronounced age-related loss of gray matter in the right hemisphere. These results are consistent with evidence that disuse leads to atrophy and suggest that age-related declines in gray matter, and perhaps function, may be limited by increasing the use of the non-dominant hand.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging / physiology*
  • Analysis of Variance
  • Brain Mapping
  • Cerebral Cortex / anatomy & histology*
  • Cerebral Cortex / physiology*
  • Functional Laterality / physiology*
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging
  • Middle Aged
  • Nerve Net / anatomy & histology
  • Nerve Net / physiology
  • Organ Size