Lupus-like histopathology in bloom syndrome: reexamining the clinical and histologic implications of photosensitivity

Am J Dermatopathol. 2009 Dec;31(8):786-91. doi: 10.1097/DAD.0b013e3181b3aa34.

Abstract

Bloom syndrome is a rare genodermatosis of autosomal recessive inheritance. Although lupus-like skin lesions characterize this disorder, mechanisms of photosensitivity are poorly understood. In this case presentation, the authors report a patient with Bloom syndrome whose lupus-like facial rash revealed striking histopathologic similarities to cutaneous lupus erythematosus.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Bloom Syndrome / complications
  • Bloom Syndrome / genetics
  • Bloom Syndrome / pathology*
  • Diagnosis, Differential
  • Humans
  • Lupus Erythematosus, Cutaneous / pathology*
  • Male
  • Photosensitivity Disorders / complications
  • Photosensitivity Disorders / genetics
  • Photosensitivity Disorders / pathology*
  • Skin Diseases / etiology
  • Skin Diseases / genetics
  • Skin Diseases / pathology*