The authors present findings from a scientific study in a 36-year-old male patient who was transferred for the evaluation of a restenosis in aortic coarctation that was initially treated by surgical repair. Contrast-enhanced magnetic resonance angiography and comprehensive flow-sensitive 4-dimensional magnetic resonance imaging for the evaluation of 3-dimensional blood flow in the entire thoracic aorta demonstrated distinct flow pattern changes associated with the disease, demonstrating a potential link between altered vascular hemodynamics and the development of vascular disease.