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Review
. 2009 Oct 7;2009(4):CD006136.
doi: 10.1002/14651858.CD006136.pub2.

Oral potassium iodide for the treatment of sporotrichosis

Siliang Xue  1 , Rui Gu, Taixiang Wu, Mingming Zhang, Xiaoshan Wang
Affiliations
Review

Oral potassium iodide for the treatment of sporotrichosis

Siliang Xue et al. Cochrane Database Syst Rev. .

Abstract

Background: Sporotrichosis is a subacute or chronic disease, usually affecting the skin caused by a dimorphic (existing in two forms), aerobic (oxygen requiring) fungus called Sporothrix schenckii. Oral potassium iodide is widely used for cutaneous sporotrichosis in clinical medicine with more and more reports published. However, the benefits and adverse reactions of these treatments have not yet been systematically reviewed.

Objectives: To assess the effects of oral potassium iodide for the treatment of sporotrichosis.

Search strategy: In July 2009 we searched the Cochrane Skin Group Specialised Skin Register, the Cochrane Central Register of Controlled Clinical Trials (CENTRAL) in The Cochrane Library (Issue 3, 2009), MEDLINE and EMBASE, The Chinese Biomedical Database, CNKI, VIP, and ongoing trials registers.

Selection criteria: Randomised trials comparing orally administered iodide with placebo, or with another treatment. Studies about potassium iodide as an adjunct were excluded.

Data collection and analysis: Two authors planned to independently assess trial quality and extract data. We also planned to collect adverse effects information from the trials where possible.

Main results: In the absence of any suitable randomised placebo-controlled trials or comparisons with other treatments in this area, we were unable to assess the effects of oral potassium iodide.

Authors' conclusions: The currently available evidence is insufficient to assess the potential for oral potassium iodide in the treatment of sporotrichosis.There is no high-quality evidence for or against oral potassium iodide as a treatment for sporotrichosis. Further randomised double-blind placebo-controlled trials are needed to define the efficacy and acceptability of these interventions.

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Conflict of interest statement

None known.

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  • doi: 10.1002/14651858.CD006136

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References

References to studies excluded from this review

Cabezas 1996 {published data only}
    1. Cabezas C, Bustamante B, Holgado W, Begue RE. Treatment of cutaneous sporotrichosis with one daily dose of potassium iodide. Pediatric Infectious Disease Journal 1996;15(4):352‐4. - PubMed

Additional references

Bonifaz 1999
    1. Bonifaz A, Saul A, Montes De Oca G, Mercadillo P. Superficial cutaneous sporotrichosis in specific anergic patient. International Journal of Dermatology 1999;38(9):700‐703. - PubMed
Carr 1995
    1. Carr MM, Fielding JC, Sibbald G, Freiberg A. Sporotrichosis of the hand: An urban experience. Journal of Hand Surgery 1995;20(1):66‐70. - PubMed
Centers for Disease Control and Prevention 2004
    1. Centers for Disease Control and Prevention. What is sporotrichosis. http://www.cdc.gov/ncidod/dbmd/diseaseinfo/sporotrichosis_g.htm#What is sporotrichosis (accessed 20 Feb 2004).
Chakrabarti 1994
    1. Chakrabarti A, Roy SK, Dhar S, Kumar B. Sporotrichosis in north‐west India. Indian Journal of Medical Research 1994;100:62‐5. - PubMed
Egger 1997
    1. Egger M, Smith GD, Schneider M, Minder C. Bias in meta‐analysis detected by a simple, graphical test. British Medical Journal 1997;315:629‐34. - PMC - PubMed
Feuerman 1976
    1. Feuerman EJ, Alteras I, Bashan D, Lehrer NB. Isolation of Sporothrix schenckii in the soil in Israel in relation to a new case in man. Sabouraudia 1976;14(2):217‐22. - PubMed
Fitzpatrick 2001
    1. Fitzpatrick TB. Sprortrichosis. In: Darlene Cooke, Mariapaz Ramos Englis, John M. Morriss editor(s). Color atlas & synopsis of clinical dermatology. 4th Edition. New York: McGraw‐Hill Companies, 2001:731.
Haddad 2002
    1. Haddad VJ, Miot HA, Bartoli LD, Cardoso Ade C, Camargo RM. Localized lymphatic sporotrichosis after fish‐induced injury (Tilapia sp). Medical Mycology 2002;40(4):425‐7. - PubMed
Hay 2003
    1. Hay RJ. Deep fungal infections. Dermatology in General Medicine 2003;2:2018.
Higgins 2008
    1. Higgins JPT, Green S, editors. Application of quality assessment criteria [Cochrane Handbook for Systematic Reviews of Interventions 5.0.0 [updated February 2008]]. The Cochrane Collaboration, 2008. Available from www.cochrane‐handbook.org.
Jones 1991
    1. Jones HE. Fungal Infections. Dermatology. Norwalk Connel: Appleton & Langec, 1991:154.
Laur 1979
    1. Laur WE, Posey RE, Waller JD. A familial epidemic of cutaneous sporotrichosis occurring in north Texas. Cutis 1979;23(2):205‐8. - PubMed
Li 2001
    1. Li SM, Liu WD. Anti‐fungus drugs. The basis of current dermatology. Beijing: People's Publishing House, 2001:991.
Lu 2000
    1. Lu Y, Lu CJ, Lin LC. In: Lu CJ editor(s). The current therapy for common skin and venereal disease. Beijing: People's Health Publishing House, 2000:543.
New York State 2004
    1. New York State. Sporotrichosis. http://www.health.state.ny.us/nysdoh/communicable_diseases/en/sporot.htm (accessed 2 April 2006).
Rajendran 1990
    1. Rajendran C, Ramesh V, Misra RS, Kandhari S. Sporotrichosis in Nepal. International Journal of Dermatology 1990;29(10):716‐8. - PubMed
Sandhu 2003
    1. Sandhu K, Gupta S. Potassium iodide remains the most effective therapy for cutaneous sporotrichosis. Journal of Dermatological Treatment 2003;14(4):200‐2. - PubMed
Sherertz 1992
    1. Sherertz EF, Callanay JL. Sporotrichosis. In: Demis JD editor(s). Clinical dermatology. Vol. 3, Philadelphia: Lippincott, 1992:17‐22.
Shinogi 2004
    1. Shinogi T, Misago N, Narisawa Y. Cutaneous sporotrichosis with refractory and reinfectious lesions in a healthy female. Dermatology 2004;31(6):492‐6. - PubMed
Stonecipher 1997
    1. Stonecipher MR. Sporotrichosis. In: D. Joseph Demis editor(s). Clinical dermatology. Vol. 3, Philadelphia: Lippincott, 1997:5.
WHO 2002
    1. World Health Organization. WHO Essential Drug list. http://mednet3.who.int/EML/expcom/expcom13/miconazole.doc (accessed 2 April 2006).
Wiederman 1992
    1. Wiederman BL. Sporotrichosis. Textbook of pediatric infectious diseases. Philadelphia: Saunders, 1992.
Wu 1999
    1. Wu Y, Li AF, Wu B, Ma LX. Clinical analysis of 38 cases of sporotrichosis. Clinical Dermatology 1999;28:290‐1.
Wu 2000
    1. Wu GF. Fungal infection. In: Wu ZH editor(s). Modern dermatology. Guangzhou: GuangDong people's Publishing House, 2000:321.
Wu 2007
    1. Taixiang Wu, Guanjian Liu. What about the concepts, design, practice and report of allocation concealment and blinding exactly?. Chinese Journal of Evidence‐Based Medicine 2007;7(3):203‐7.

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