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, 54 (4), 478-81

Binding Profile of SM-9018, a Novel Antipsychotic Candidate

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Binding Profile of SM-9018, a Novel Antipsychotic Candidate

T Kato et al. Jpn J Pharmacol.

Abstract

The present study employed various receptor-binding assays to clarify the biochemical characteristics of SM-9018. SM-9018 possessed very high affinity for 5-HT2, D2 and 5-HT1A receptors (Ki = 0.61, 1.4 and 2.9 nM, respectively), and it had moderate affinity for alpha 1 and D1 receptors (Ki = 17 and 41 nM, respectively). However, SM-9018 had only negligible affinity for alpha 2, opiate, glutamate, phencyclidine, benzodiazepine and GABAA receptors. These results suggest that SM-9018 may be a novel antipsychotic agent with binding affinity for 5-HT2 and 5-HT1A receptors.

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Cited by 3 PubMed Central articles

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