The Comparative Oncology Trials Consortium: using spontaneously occurring cancers in dogs to inform the cancer drug development pathway

PLoS Med. 2009 Oct;6(10):e1000161. doi: 10.1371/journal.pmed.1000161. Epub 2009 Oct 13.


Chand Khanna and colleagues describe the work of the Comparative Oncology Trials Consortium (COTC), which provides infrastructure and resources to integrate naturally occurring dog cancer models into the development of new human cancer drugs, devices, and imaging techniques.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Animals
  • Animals, Domestic
  • Antineoplastic Agents / therapeutic use
  • Clinical Trials as Topic / veterinary*
  • Clinical Trials, Phase I as Topic
  • Dog Diseases / drug therapy*
  • Dogs
  • Drug Screening Assays, Antitumor*
  • Humans
  • Models, Animal*
  • Multicenter Studies as Topic / veterinary*
  • National Cancer Institute (U.S.) / organization & administration*
  • Neoplasms / drug therapy
  • Neoplasms / veterinary*
  • Species Specificity
  • United States


  • Antineoplastic Agents