Recent trends and challenges in complex organ manufacturing

Tissue Eng Part B Rev. 2010 Apr;16(2):189-97. doi: 10.1089/ten.TEB.2009.0576.


Presently, there is a recognized and imperative need for bioartificial organs. The technological advances in transgenosis, tissue engineering, and rapid prototyping have led to the development of spatially complex tissues. An ideal artificial organ should provide nutrient transport system, mechanical stable architecture, and synergetic multicellular organization in one construct. The multinozzle rapid prototyping technique simultaneously assembles vascular systems including hierarchical multicellular structures in an automated and reproducible manner and offers an effective way for treating organ failures. In this article, a brief overview of the recent trends and outstanding challenges in organ manufacturing is provided. From the viewpoint of disciplinary crossing, integration, and development, future directions in the coming years were pointed out.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animal Structures / cytology
  • Animal Structures / physiology*
  • Animal Structures / ultrastructure
  • Animals
  • Humans
  • Models, Anatomic
  • Models, Biological
  • Organ Culture Techniques / instrumentation
  • Organ Culture Techniques / methods
  • Tissue Engineering / instrumentation
  • Tissue Engineering / methods*
  • Tissue Engineering / trends*