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Review
, 21 Suppl 2 (Suppl 2), 20-30

Pathophysiology of Colonic Causes of Chronic Constipation

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Review

Pathophysiology of Colonic Causes of Chronic Constipation

P G Dinning et al. Neurogastroenterol Motil.

Abstract

Colonic sensorimotor dysfunction is recognized as the principal pathophysiological mechanism underpinning chronic constipation. This review addresses current understanding derived from both human and animal studies, with particular reference made to methods of investigation.

Conflict of interest statement

CONFLICTS OF INTEREST: PD has no conflict of interest for this paper but has received funding from Medtronic Australiasia/USA and research support from NHMRC Australia.

MS has no conflict of interest with regards to this paper. In the past 2 years, he has received grant funding from SmartPill Corporation, USA to support novel studies of GI transit, and from GSK to help develop technology for the evaluation of GI sensory function.

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