Abstract
The developmental origins of brown adipose tissue and white adipose tissue are distinct, with brown adipocytes being derived from muscle precursors. PR domain containing 16, together with C/EBPbeta, forms a lineage-switching transcriptional complex which promotes brown fat differentiation and suppresses muscle cell differentiation.
MeSH terms
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Adipocytes, Brown / cytology
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Adipocytes, Brown / metabolism*
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Adipose Tissue, Brown / cytology
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Adipose Tissue, Brown / metabolism*
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Animals
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CCAAT-Enhancer-Binding Protein-beta / genetics
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CCAAT-Enhancer-Binding Protein-beta / metabolism
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Cell Differentiation
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism
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Humans
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Mice
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Transcription Factors / genetics
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Transcription Factors / metabolism
Substances
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CCAAT-Enhancer-Binding Protein-beta
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DNA-Binding Proteins
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Prdm16 protein, mouse
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Transcription Factors