The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression

Oncogene. 2010 Jan 7;29(1):1-10. doi: 10.1038/onc.2009.325. Epub 2009 Oct 12.


Deregulation of the G1/G0 phase of the cell cycle can lead to cancer. During G1, most cells commit alternatively to DNA replication and division, or to cell-cycle exit and differentiation. The anaphase-promoting complex or cyclosome (APC/C) activated by Cdh1 coordinately eliminates positive cell-cycle regulators as well as inhibitors of differentiation, thereby coupling cell-cycle exit and differentiation. Misregulation of Cdh1 thus has the potential to promote both cell-cycle re-entry and either perturbed differentiation or dedifferentiation. In addition, APC/C(Cdh1) is required to maintain genomic stability. As a result, loss of Cdh1 can contribute to tumorigenesis in the form of proliferation of poorly differentiated and genetically unstable cells.

Publication types

  • Review

MeSH terms

  • Anaphase-Promoting Complex-Cyclosome
  • Animals
  • Cell Cycle / physiology
  • Cell Cycle Proteins / metabolism
  • Cell Cycle Proteins / physiology*
  • Cell Differentiation / physiology*
  • Cell Proliferation
  • Genomic Instability*
  • Humans
  • Models, Biological
  • Neoplasms / genetics
  • Neoplasms / pathology
  • Neoplasms / physiopathology*
  • Ubiquitin-Protein Ligase Complexes / metabolism*


  • Cell Cycle Proteins
  • Ubiquitin-Protein Ligase Complexes
  • Anaphase-Promoting Complex-Cyclosome