Use of lung cancer risk models in planning research and service programs in CT screening for lung cancer

Expert Rev Anticancer Ther. 2009 Oct;9(10):1467-72. doi: 10.1586/era.09.87.


Computed tomography screening for lung cancer is now being tested in a number of international trials. The long-term success of the approach in the future National Screening Programme is dependent upon identifying populations at sufficient risk of lung cancer that the benefit-harm ratio of the intervention is likely to be high. There are a number of lung cancer risk prediction models currently available. We review these, and demonstrate, using the Liverpool Lung Project risk prediction model as a case study, the potential for use of a risk prediction model in the design of a randomized trial of lung cancer screening and in the planning of a service screening program.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • Lung Neoplasms / diagnosis*
  • Lung Neoplasms / etiology
  • Mass Screening / methods
  • Models, Statistical*
  • Program Development / methods
  • Risk
  • Risk Factors
  • Tomography, X-Ray Computed / methods*