Features of intrathecal immunoglobulins in patients with multiple sclerosis

J Neurol Sci. 2010 Jan 15;288(1-2):147-50. doi: 10.1016/j.jns.2009.09.016. Epub 2009 Oct 13.


We have analyzed immunoglobulin (Ig) isotypes and IgG subclasses in cerebrospinal fluid (CSF) and serum of patients with multiple sclerosis (MS) and other neurological diseases to determine whether different Ig isotype patterns correlate with clinical or paraclinical findings and CSF B cell populations. Intrathecal IgG1 synthesis was elevated in MS patients. An increased intrathecal IgM production was found in patients with a higher cerebral MRI lesion burden, whereas other clinical and paraclinical parameters were not associated with a specific Ig isotype or subclass profile. Finally, intrathecal IgG production (IgG1 and IgG3) correlated with the presence of mature B cells and plasma blasts.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • B-Lymphocytes
  • Cerebrospinal Fluid / cytology
  • Female
  • Flow Cytometry
  • Humans
  • Immunoglobulin G / cerebrospinal fluid
  • Immunoglobulins / cerebrospinal fluid*
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Multiple Sclerosis, Relapsing-Remitting / cerebrospinal fluid*
  • Multiple Sclerosis, Relapsing-Remitting / pathology
  • Nervous System Diseases / cerebrospinal fluid
  • Young Adult


  • Immunoglobulin G
  • Immunoglobulins