Magnesium and headache after aneurysmal subarachnoid haemorrhage

J Neurol Neurosurg Psychiatry. 2010 May;81(5):490-3. doi: 10.1136/jnnp.2009.181404. Epub 2009 Oct 13.


Background: In patients with aneurysmal subarachnoid haemorrhage (SAH), headache typically is severe and often requires treatment with opioids. Magnesium has analgesic effects in several conditions, but whether it reduces headache after SAH is unknown.

Methods: In a cohort of 108 SAH patients included in the randomised controlled trial Magnesium in Aneurysmal Subarachnoid Haemorrhage-II (MASH-II), severity of headache was regularly assessed on an 11-point scale until day 10 after SAH. Headache was treated according to a standardised protocol with acetaminophen, codeine, tramadol or piritramide. Serum magnesium levels were assessed every other day. Differences in mean headache scores between patients with mean high (>1.0 mmol/l) and normal (< or =1.0 mmol/l) magnesium levels were analysed with a Student t test. Crude and adjusted ORs for the use of codeine, tramadol and piritramide for patients with high versus normal magnesium levels were calculated with logistic regression.

Results: The 61 patients with high magnesium levels had lower mean headache scores (4.1) than the 47 patients with normal magnesium levels (4.9; mean difference, 0.8; 95% CI 0.1 to 1.6) and required less tramadol (adjusted OR, 0.3; 95% CI 0.1 to 0.7) or piritramide (adjusted OR 0.2; 95% CI 0.1 to 0.5). There were no differences in the use of acetaminophen or codeine.

Conclusion: In SAH patients, elevated serum magnesium levels are associated with slightly less severe headache and less frequent use of opioids. These data imply that intravenous magnesium therapy, besides a supposed beneficial effect on outcome, also provides pain relief for SAH patients, for whom it might also improve functional outcome.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analgesics / administration & dosage
  • Analgesics / therapeutic use*
  • Analgesics, Opioid / therapeutic use
  • Codeine / therapeutic use
  • Female
  • Headache / drug therapy*
  • Headache / etiology*
  • Humans
  • Injections, Intravenous
  • Logistic Models
  • Magnesium Sulfate / administration & dosage
  • Magnesium Sulfate / therapeutic use*
  • Male
  • Middle Aged
  • Pain Measurement
  • Pirinitramide / therapeutic use
  • Stroke / complications
  • Stroke / etiology
  • Subarachnoid Hemorrhage / complications*
  • Tramadol / therapeutic use


  • Analgesics
  • Analgesics, Opioid
  • Tramadol
  • Pirinitramide
  • Magnesium Sulfate
  • Codeine