How autophagy regulates the host cell signaling associated with the postpartum bacteria cocoon experienced as a danger signal

Autophagy. 2009 Nov;5(8):1222-3. doi: 10.4161/auto.5.8.10218. Epub 2009 Nov 1.


Shigella, the causative agent of human bacillary dysentery, invades the host cell, rapidly breaking the phagosome and multiplying in the cytosol. Here, we summarize our recent work showing the targeting of the leftover membrane remnants to autophagy together with trapped membrane-associated signaling molecules recruited during the immediate early entry step. We suggest that this mechanism participates in the bacteria-dependent orchestration of the cell response. Moreover, we propose that this signaling node may have relevance as to how the cell interprets endomembrane damage triggered by other stimuli.

MeSH terms

  • Autophagy*
  • Epithelial Cells / cytology
  • Epithelial Cells / metabolism
  • Epithelial Cells / microbiology
  • Host-Pathogen Interactions*
  • Humans
  • Mitochondria / metabolism
  • Shigella / physiology*
  • Signal Transduction*
  • Ubiquitination