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. 2009 Nov 1;8(21):3474-9.
doi: 10.4161/cc.8.21.9846. Epub 2009 Nov 18.

Paradoxical Roles of FAK in Tumor Cell Migration and Metastasis

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Paradoxical Roles of FAK in Tumor Cell Migration and Metastasis

Yanhua Zheng et al. Cell Cycle. .

Abstract

Focal adhesion kinase (FAK), as a key mediator of signaling induced by integrins, plays an instrumental role in many cellular functions, including cell survival and proliferation. Many studies have reported that FAK is a positive regulator of normal cell migration and cancer cell metastasis. However, emerging evidence shows that FAK--under certain oncogenic signaling, such as that initiated by activated Ras and some growth factor receptor kinases--negatively regulates cancer cell migration. Activated Ras may promote tumor cell migration by dephosphorylation of FAK at Y397 and facilitation of focal adhesion turnover at the leading edge of cells.

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