The emerging role of apelin in cardiovascular disease and health

Cardiol Rev. 2009 Nov-Dec;17(6):283-6. doi: 10.1097/CRD.0b013e3181b3fe0d.


This article focuses on a newly discovered bioactive peptide, termed apelin, as it relates to the cardiovascular system. Apelin, through its G-protein coupled receptor, seems to primarily exert effects in blood pressure control, and may play a role in heart failure and in myocardial reperfusion injury. In addition, at least some of apelin's effects appear to stem from an interaction with the renin-angiotensin system. Apelin may provide a target for drug treatment of cardiovascular disease.

Publication types

  • Review

MeSH terms

  • Apelin
  • Blood Pressure / physiology
  • Cardiovascular Diseases / physiopathology*
  • Cardiovascular Physiological Phenomena*
  • Heart Failure / physiopathology
  • Humans
  • Intercellular Signaling Peptides and Proteins / physiology*
  • Myocardial Reperfusion Injury / physiopathology
  • Renin-Angiotensin System / physiology


  • APLN protein, human
  • Apelin
  • Intercellular Signaling Peptides and Proteins