Chronic proton pump inhibitor therapy associated with increased development of fundic gland polyps

Dig Dis Sci. 2009 Dec;54(12):2617-22. doi: 10.1007/s10620-009-0993-z. Epub 2009 Oct 15.


Background: Fundic gland polyps (FGP) have been implicated with long-term proton pump inhibitor (PPI) use.

Aims: We attempted to investigate the impact of length and dosage of PPI therapy on the development of FGP.

Methods: A retrospective cohort study of all patients who had gastric polyps removed during elective upper endoscopy between March and September 2007 as part of a prior prospective study protocol was carried out. FGP were determined histologically. Prior to endoscopy, all patients completed a questionnaire regarding PPI use and length of therapy (no PPI use, 1-48 months, >48 months). The dosage of PPI was obtained via a thorough chart review of electronic medical records.

Results: Three hundred and eighty-five patients completed upper endoscopy and a questionnaire reporting PPI use (252 [65.4%] patients on PPI). On endoscopy, 55 patients had polyps, with the majority (43/55, 78%) being FGP, resulting in an overall prevalence of 11.1% (43/385). On univariate analysis, FGP were associated with Caucasian race (15 vs. 6%; P=0.009) and chronic PPI therapy (>48 months) (31.9 vs. 7.5%, P<0.001). There was a significant linear-by-linear association between PPI dosage and FGP prevalence (no PPI use, 7.5%; once daily, 10.8%; twice daily 17.4%, P=0.026). On logistic regression, the only independent predictor of FGP was duration of PPI use >48 months (P=0.001, odds ratio [OR] 4.7 [2.0-12.9]).

Conclusions: The only independent predictor of FGP development in our study was duration of PPI therapy greater than 48 months. Increased dosage of therapy did not significantly impact the development of FGP.

MeSH terms

  • Adult
  • Aged
  • District of Columbia
  • Drug Administration Schedule
  • Female
  • Gastric Fundus / drug effects*
  • Gastric Fundus / pathology
  • Gastric Fundus / surgery
  • Gastroscopy
  • Hospitals, Military
  • Humans
  • Linear Models
  • Logistic Models
  • Male
  • Middle Aged
  • Odds Ratio
  • Polyps / chemically induced*
  • Polyps / pathology
  • Polyps / surgery
  • Proton Pump Inhibitors / administration & dosage
  • Proton Pump Inhibitors / adverse effects*
  • Retrospective Studies
  • Risk Assessment
  • Risk Factors
  • Stomach Diseases / chemically induced*
  • Stomach Diseases / pathology
  • Stomach Diseases / surgery
  • Surveys and Questionnaires
  • Time Factors


  • Proton Pump Inhibitors