[Combined vaccines including 1 or several anti-foot-and-mouth valences]

Dev Biol Stand. 1976:35:395-407.
[Article in French]


Combined vaccines are used for many human and animal diseases. However, we have very few examples of combinations containing anti-foot-and-mouth valence which would allow easy immunization against differnet diseases without additional handling. Until now foot-and-mouth vaccination has been applied simultaneously with anti-brucellic vaccination (Baldoni, Renoux), andi-anthrax (Nobili) and vaccination against swine fever and Aujeszky's disease (Lysenko). During the last ten years we have particularly studied the association of anti-foot-and-mouth disease vaccines with anti-brucella and anti-rabies vaccines. We have shown the possiblity of combining these different antigens, either in classical aqueous vaccines in aluminum hydroxide, or in emulsified vaccines containing oily adjuvants. The anti-brucella valences may be agglutinogenic (H 38) or non-agglutinogenic (MacEwen 45/20). The combined vaccines "rabies + foot-and-mouth disease" and "brucellosis + foot-and-mouth disease" can be produced on an industrial scale. For many years millions of animals have been successfully vaccinated in France by means of a combined "rabies + foot-and-mouth disease" vaccine.

MeSH terms

  • Adjuvants, Immunologic / administration & dosage
  • Aluminum Hydroxide / administration & dosage
  • Animals
  • Aphthovirus / immunology*
  • Brucella Vaccine / administration & dosage
  • Brucella abortus / immunology
  • Brucellosis, Bovine / prevention & control
  • Cattle
  • Cattle Diseases / prevention & control
  • Foot-and-Mouth Disease / prevention & control
  • Oils / administration & dosage
  • Rabies / prevention & control
  • Rabies / veterinary
  • Rabies Vaccines / administration & dosage
  • Saponins / administration & dosage
  • Viral Vaccines* / administration & dosage


  • Adjuvants, Immunologic
  • Brucella Vaccine
  • Oils
  • Rabies Vaccines
  • Saponins
  • Viral Vaccines
  • Aluminum Hydroxide