Effect of myrcene on nociception in mice

J Pharm Pharmacol. 1990 Dec;42(12):877-8. doi: 10.1111/j.2042-7158.1990.tb07046.x.


Myrcene, a monoterpene isolated from lemon grass oil (Cymbopogon citratus) has been investigated for antinociception in mice by a low temperature (51.5 +/- 0.5 degrees C) hot plate method and by the acetic acid-induced writhing test. Significant inhibition of nociception was seen in the tests with myrcene at doses of 10 and 20 mg kg-1 (i.p.) or at 20 and 40 mg kg-1 (s.c.), respectively. The antinociceptive effect was significantly antagonized by naloxone (1 mg kg-1) or yohimbine (2 mg kg-1). The results suggest that myrcene is capable of inducing antinociception in mice, probably mediated by alpha 2-adrenoceptor stimulated release of endogenous opioids.

MeSH terms

  • Acyclic Monoterpenes
  • Animals
  • Injections, Intraperitoneal
  • Male
  • Mice
  • Monoterpenes*
  • Pain / prevention & control*
  • Reaction Time
  • Terpenes / therapeutic use*


  • Acyclic Monoterpenes
  • Monoterpenes
  • Terpenes
  • beta-myrcene