T Cell-Mediated Control of Epstein-Barr Virus Infection in Humanized Mice

J Infect Dis. 2009 Nov 15;200(10):1611-5. doi: 10.1086/644644.

Abstract

Humanized NOD/Shi-scid/interleukin-2Rgamma(null) (NOG) mice with full T cell development had significantly longer life span after Epstein-Barr virus (EBV) infection, compared with those with minimal T cell development. Removing CD3(+) or CD8(+) T cells from EBV-infected humanized mice by administration of anti-CD3 or anti-CD8 antibodies reduced their life span. CD8(+) T cells obtained from EBV-infected mice suppressed the outgrowth of autologous B cells isolated from uninfected mice and inoculated with EBV in vitro. These results indicate that humanized NOG mice are capable of T cell-mediated control of EBV infection and imply their usefulness as a tool to evaluate immunotherapeutic and prophylactic strategies for EBV infection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • B-Lymphocytes / immunology
  • B-Lymphocytes / virology
  • CD3 Complex / immunology
  • CD8-Positive T-Lymphocytes / immunology*
  • CD8-Positive T-Lymphocytes / virology
  • Disease Models, Animal*
  • Epstein-Barr Virus Infections / immunology*
  • Female
  • Humans
  • Immunity, Cellular / immunology
  • Longevity / immunology
  • Mice
  • T-Lymphocyte Subsets / immunology*
  • T-Lymphocyte Subsets / virology

Substances

  • CD3 Complex