Ketoprofen allergic reactions

Recent Pat Inflamm Allergy Drug Discov. 2010 Jan;4(1):58-64. doi: 10.2174/187221310789895595.


Topical ketoprofen (KP) is widely used because of its anti-inflammatory effect. Parallel with its popular usage, the number of reported cases of ketoprofen-induced photoallergic contact dermatitis has increased. A review of the literature was made to evaluate the spectrum of cross sensitization in patients with ketoprofen-induced photoallergic contact dermatitis using ketoprofen and other structurally similar chemicals and sunscreens, fragrance components, as well as the presence of prolonged photosensitivity related to it. Furthermore, the distinction between true cross-reactivity and concomitant sensitization may be difficult. Therefore, further investigations are needed to gain a more complete understanding of this important topic. This article also reviews some patents related to alternative treatment of musculoskeletal diseases and/or treatment of allergic reactions due to NSAIDs use.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Cross Reactions / immunology
  • Dermatitis, Photoallergic / etiology
  • Dermatitis, Photoallergic / immunology*
  • Drug Delivery Systems
  • Drug Hypersensitivity / etiology
  • Drug Hypersensitivity / immunology*
  • Humans
  • Ketoprofen / adverse effects*
  • Ketoprofen / chemistry
  • Ketoprofen / therapeutic use
  • Musculoskeletal Diseases / drug therapy*
  • Patents as Topic


  • Anti-Inflammatory Agents, Non-Steroidal
  • Ketoprofen