Natural autoantibodies to apoptotic cell membranes regulate fundamental innate immune functions and suppress inflammation

Discov Med. 2009 Oct;8(42):151-6.

Abstract

The evolution of the immune system has provided a multilevel system that interconnects the innate and adaptive immune systems to serve at least three central purposes: the defense from microbial pathogens, the capacity for discrimination of self- from non-self necessary for the prevention of autoimmune disease, and essential effector roles in wound repair and tissue remodeling. In recent studies, we have elucidated an unsuspected role for a class of naturally occurring autoreactive antibodies from the most primitive tier of B lymphocytes, which regulates fundamental functions of the innate immune system. Our findings also throw light onto long unresolved mysteries regarding the origins of the earliest waves of B lymphocyte development.

MeSH terms

  • Animals
  • Apoptosis / immunology*
  • Autoantibodies / immunology*
  • Cell Membrane / immunology*
  • Humans
  • Immunity, Innate / immunology*
  • Inflammation / immunology*

Substances

  • Autoantibodies