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Review
. 2009 Oct;8(42):157-64.

Novel Therapeutics Approaches to Chronic Lymphocytic Leukemia Based on Recent Biological Insights

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  • PMID: 19833065
Free article
Review

Novel Therapeutics Approaches to Chronic Lymphocytic Leukemia Based on Recent Biological Insights

Tanja N Hartmann et al. Discov Med. .
Free article

Abstract

Chronic lymphocytic leukemia (CLL) is a malignancy mainly affecting elderly people and is still considered an incurable disease. Despite recent advances in CLL treatment, relapse rates are high and often accompanied by the development of resistance towards conventional chemotherapy. Thus, new agents are needed for the treatment of these patients. In recent years, our understanding of the biological mechanisms driving CLL pathogenesis has considerably improved, and novel treatment strategies are arising. This review summarizes recent insights in CLL biology and describes several new agents and treatment strategies that are currently explored in pre-clinical studies and early-phase clinical trials.

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