The Key Role of Segmented Filamentous Bacteria in the Coordinated Maturation of Gut Helper T Cell Responses

Immunity. 2009 Oct 16;31(4):677-89. doi: 10.1016/j.immuni.2009.08.020.

Abstract

Microbiota-induced cytokine responses participate in gut homeostasis, but the cytokine balance at steady-state and the role of individual bacterial species in setting the balance remain elusive. Herein, systematic analysis of gnotobiotic mice indicated that colonization by a whole mouse microbiota orchestrated a broad spectrum of proinflammatory T helper 1 (Th1), Th17, and regulatory T cell responses whereas most tested complex microbiota and individual bacteria failed to efficiently stimulate intestinal T cell responses. This function appeared the prerogative of a restricted number of bacteria, the prototype of which is the segmented filamentous bacterium, a nonculturable Clostridia-related species, which could largely recapitulate the coordinated maturation of T cell responses induced by the whole mouse microbiota. This bacterium, already known as a potent inducer of mucosal IgA, likely plays a unique role in the postnatal maturation of gut immune functions. Changes in the infant flora may thus influence the development of host immune responses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bacteroidetes / immunology
  • Clostridium / immunology*
  • Cytokines / immunology
  • Cytokines / metabolism*
  • Escherichia coli / immunology
  • Female
  • Gene Expression
  • Germ-Free Life
  • Interleukin-17 / immunology
  • Intestines / immunology*
  • Intestines / microbiology
  • Intestines / ultrastructure
  • Mice
  • Mice, Inbred C3H
  • Microscopy, Electron, Scanning
  • Peyer's Patches / immunology*
  • Peyer's Patches / metabolism
  • Peyer's Patches / microbiology
  • T-Lymphocytes, Regulatory / immunology*
  • T-Lymphocytes, Regulatory / microbiology
  • Th1 Cells / immunology*
  • Th1 Cells / microbiology

Substances

  • Cytokines
  • Interleukin-17

Associated data

  • PDB/GSE18056