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Review
. 2009 Nov;7(11):798-812.
doi: 10.1038/nrmicro2223.

Understanding HIV-1 Latency Provides Clues for the Eradication of Long-Term Reservoirs

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Review

Understanding HIV-1 Latency Provides Clues for the Eradication of Long-Term Reservoirs

Mayte Coiras et al. Nat Rev Microbiol. .

Abstract

HIV-1 can infect both activated and resting, non-dividing cells, following which the viral genome can be permanently integrated into a host cell chromosome. Latent HIV-1 reservoirs are established early during primary infection and constitute a major barrier to eradication, even in the presence of highly active antiretroviral therapy. This Review analyses the molecular mechanisms that are necessary for the establishment of HIV-1 latency and their relationships with different cellular and anatomical reservoirs, and discusses the current treatment strategies for targeting viral persistence in reservoirs, their main limitations and future perspectives.

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