Refractory urinary tract and vulvovaginal infection caused by Candida krusei

Int Urogynecol J Pelvic Floor Dysfunct. 2009 Nov;20(11):1379-81. doi: 10.1007/s00192-009-0869-y. Epub 2009 Apr 1.

Abstract

Candida krusei is an uncommon cause of vaginitis and cystitis but is unique because of the management challenge it poses due to intrinsic resistance to fluconazole and flucytosine. We report a case of C. krusei vaginitis and cystitis successfully managed with topical vaginal and intravesical amphotericin B. The challenges in managing C. krusei cystitis and the role of amphotericin B bladder irrigation in the management of fungal urinary tract infections are discussed.

Publication types

  • Case Reports

MeSH terms

  • Administration, Topical
  • Amphotericin B / administration & dosage
  • Amphotericin B / pharmacology
  • Amphotericin B / therapeutic use*
  • Antifungal Agents / administration & dosage
  • Antifungal Agents / pharmacology
  • Antifungal Agents / therapeutic use*
  • Candida / drug effects
  • Candida / physiology*
  • Candidiasis, Vulvovaginal / diagnosis
  • Candidiasis, Vulvovaginal / drug therapy*
  • Candidiasis, Vulvovaginal / microbiology
  • Drug Resistance, Fungal / drug effects
  • Drug Resistance, Fungal / physiology*
  • Female
  • Humans
  • Middle Aged
  • Treatment Outcome
  • Urinary Tract Infections / diagnosis
  • Urinary Tract Infections / drug therapy*
  • Urinary Tract Infections / microbiology

Substances

  • Antifungal Agents
  • Amphotericin B