Evaluation of seasonal patterns of Kawasaki syndrome- and rotavirus-associated hospitalizations in California and New York, 2000-2005

BMC Pediatr. 2009 Oct 16;9:65. doi: 10.1186/1471-2431-9-65.


Background: Kawasaki Syndrome (KS) is an uncommon childhood disease with unknown etiology. It has been suggested that rotavirus infection may play a causative role in the development of KS.

Methods: To examine potential temporal associations between KS and rotavirus infection, seasonal patterns of KS- and rotavirus-associated hospitalizations among children in California and New York during 2000-2005 were compared.

Results: Rotavirus hospital admissions were markedly winter seasonal, with very few summer hospitalizations. KS hospitalizations occurred year-round but also peaked slightly during winter and spring.

Conclusion: The strong winter seasonal pattern of rotavirus clearly differed from the year-round pattern of KS hospitalizations. While the present study cannot completely rule out rotavirus as having a role in the development of KS, other agents must be involved in the etiology of KS.

Publication types

  • Comparative Study
  • Multicenter Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • California / epidemiology
  • Child, Preschool
  • Hospitalization / trends*
  • Humans
  • Incidence
  • Mucocutaneous Lymph Node Syndrome / epidemiology*
  • Mucocutaneous Lymph Node Syndrome / etiology
  • Mucocutaneous Lymph Node Syndrome / therapy
  • New York / epidemiology
  • Prevalence
  • Retrospective Studies
  • Risk Factors
  • Rotavirus Infections / complications
  • Rotavirus Infections / epidemiology*
  • Rotavirus Infections / therapy
  • Seasons*