Solid phase synthesis of acylglycine human metabolites

Bioorg Med Chem Lett. 2009 Dec 1;19(23):6706-8. doi: 10.1016/j.bmcl.2009.09.118. Epub 2009 Oct 3.


Acylglycines represents a large and important class of human metabolites. They are often used in medicine to identify fatty acid oxidation disorders. A highly efficient solid phase synthesis approach to obtain these clinically important compounds is developed via coupling reaction between glycine-preloaded Wang resin and a set of carboxylic acids. The developed methodology facilitates the preparation of several structurally-diverse acylglycines with high yields and purity.

MeSH terms

  • Glycine / analogs & derivatives
  • Glycine / chemical synthesis*
  • Glycine / metabolism*
  • Humans
  • Molecular Structure
  • Stereoisomerism


  • Glycine