Ferrying wingless across the synaptic cleft

Cell. 2009 Oct 16;139(2):229-31. doi: 10.1016/j.cell.2009.09.032.

Abstract

Secreted Wnt morphogens mediate cell-cell communication, but the mechanism of Wnt transfer between cells is unknown. Korkut et al. (2009) report that the transmembrane protein Evi is a versatile carrier that guides Wingless to presynaptic terminals of motor neurons and then escorts it across the synaptic cleft. In postsynaptic muscles, Evi promotes Frizzled-2 trafficking.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Comment

MeSH terms

  • Animals
  • Drosophila / metabolism*
  • Drosophila Proteins / metabolism
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Protein Transport
  • Synapses*
  • Wnt1 Protein / metabolism

Substances

  • Drosophila Proteins
  • Intracellular Signaling Peptides and Proteins
  • Wls protein, Drosophila
  • Wnt1 Protein
  • wg protein, Drosophila