Abstract
Secreted Wnt morphogens mediate cell-cell communication, but the mechanism of Wnt transfer between cells is unknown. Korkut et al. (2009) report that the transmembrane protein Evi is a versatile carrier that guides Wingless to presynaptic terminals of motor neurons and then escorts it across the synaptic cleft. In postsynaptic muscles, Evi promotes Frizzled-2 trafficking.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Comment
MeSH terms
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Animals
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Drosophila / metabolism*
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Drosophila Proteins / metabolism
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Intracellular Signaling Peptides and Proteins / metabolism
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Protein Transport
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Synapses*
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Wnt1 Protein / metabolism
Substances
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Drosophila Proteins
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Intracellular Signaling Peptides and Proteins
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Wls protein, Drosophila
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Wnt1 Protein
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wg protein, Drosophila