Mining the B cell repertoire for broadly neutralizing monoclonal antibodies to HIV-1

Cell Host Microbe. 2009 Oct 22;6(4):292-4. doi: 10.1016/j.chom.2009.09.008.


Monoclonal antibodies that effectively neutralize HIV-1 have been widely sought, yet few have been isolated. Now, technological advances in sera evaluation, B cell stimulation, microneutralization, and antibody cloning have allowed Burton and colleagues to identify two broadly neutralizing monoclonal antibodies, PG9 and PG16, which provide insights for HIV vaccine design.

MeSH terms

  • Antibodies, Monoclonal / immunology*
  • Antibodies, Monoclonal / isolation & purification
  • Antibodies, Neutralizing / immunology*
  • Antibodies, Neutralizing / isolation & purification
  • B-Lymphocytes / immunology*
  • HIV Antibodies / immunology*
  • HIV Antibodies / isolation & purification
  • HIV-1 / immunology*
  • Humans
  • Models, Biological


  • Antibodies, Monoclonal
  • Antibodies, Neutralizing
  • HIV Antibodies