Design and characteristics of holographic neural photo-stimulation systems

J Neural Eng. 2009 Dec;6(6):066004. doi: 10.1088/1741-2560/6/6/066004. Epub 2009 Oct 16.


Computer-generated holography is an emerging technology for stimulation of neuronal populations with light patterns. A holographic photo-stimulation system may be designed as a powerful research tool or a compact neural interface medical device, such as an optical retinal prosthesis. We present here an overview of the main design issues including the choice of holographic device, field-of-view, resolution, physical size, generation of two- and three-dimensional patterns and their diffraction efficiency, choice of algorithms and computational effort. The performance and characteristics of a holographic pattern stimulation system with kHz frame rates are demonstrated using experimental recordings from isolated retinas.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Automation
  • Electronics, Medical / instrumentation*
  • Electronics, Medical / methods*
  • Equipment Design
  • Holography / instrumentation*
  • Holography / methods*
  • Humans
  • Light
  • Microscopy / instrumentation
  • Microscopy / methods
  • Microtechnology / instrumentation
  • Microtechnology / methods
  • Neurons / physiology*
  • Optics and Photonics / instrumentation
  • Optics and Photonics / methods
  • Photic Stimulation
  • Retina / physiology
  • Signal Processing, Computer-Assisted
  • Time Factors
  • User-Computer Interface