The use of fibrin sealant as a glue for septoplasty and conchotomy

Rhinology. 2009 Sep;47(3):297-300. doi: 10.4193/Rhin08.156.


Objective: The aim of our study was to investigate glue properties of a fibrin sealant in cases of septoplasty and conchotomy.

Design: Double-blind prospective randomized study.

Materials and methods: A study of 146 patients (80 M, 66 F) who underwent septoplasty and conchotomy was performed in Assaf Harofeh Medical Center Tzrifin, Israel. The patients were divided randomly into two groups: Group I (n = 74) underwent septoplasty with transseptal suturing, and conchotomy with glue as a haemostatic. Group II (n = 72) underwent septoplasty and conchotomy with glue as a haemostatic as well as septal cartilage and mucoperichodrial flaps sealant (no transseptal suturing). The glue was based on a concentrate of human clottable proteins and purified native human thrombin.

Results: Our results showed complete healing in both groups without significant differences. One late postoperative nasal bleeding occurred in group I, and none in group II.

Conclusion: We conclude that the use of second-generation glue in endonasal surgery is well suited to stop nasal bleeding and seal intranasal flaps. Moreover, it might help to avoid transseptal suturing.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Double-Blind Method
  • Female
  • Hemostatics / therapeutic use*
  • Humans
  • Male
  • Nasal Septum / surgery*
  • Turbinates / surgery*


  • Hemostatics