Helicobacter pylori infection and gastropathy: a comparison between Indonesian and Japanese patients

World J Gastroenterol. 2009 Oct 21;15(39):4928-31. doi: 10.3748/wjg.15.4928.

Abstract

Aim: To compare the effects of Helicobacter pylori (H. pylori) infection on gastropathy between Indonesian and Japanese patients.

Methods: Biopsy specimens were obtained during upper gastrointestinal endoscopy from 167 subjects (125 Indonesians and 42 Japanese) with uninvestigated symptoms of dyspepsia. The specimens were analyzed for the presence of H. pylori using urease analysis, histopathology, and cell culture. The grade and activity of gastritis was assessed using the updated Sydney system.

Results: The percentages of Indonesian and Japanese patients who were H. pylori-positive at the antrum or body of the stomach were similar (68% and 59.5%, respectively; P = 0.316). Of those who were H. pylori-positive, more Japanese patients than Indonesian patients had high levels of polymorphonuclear cells (P = 0.001), mononuclear cells (P = 0.013), glandular atrophy (P = 0.000), and intestinal metaplasia (P = 0.011) in both the antrum and body of the stomach.

Conclusion: The grade of gastritis and prevalence of mucosal atrophy and intestinal metaplasia were higher in Japanese patients. The difference between Indonesian and Japanese patients was significant.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Asian Continental Ancestry Group / statistics & numerical data*
  • Atrophy
  • Biopsy
  • Cells, Cultured
  • Disease Progression
  • Dyspepsia / ethnology
  • Dyspepsia / microbiology
  • Female
  • Gastric Mucosa / microbiology
  • Gastric Mucosa / pathology
  • Gastritis, Atrophic / ethnology*
  • Gastritis, Atrophic / microbiology
  • Gastritis, Atrophic / pathology
  • Gastroscopy
  • Helicobacter Infections / ethnology*
  • Helicobacter Infections / microbiology
  • Helicobacter Infections / pathology
  • Helicobacter pylori / enzymology
  • Helicobacter pylori / pathogenicity*
  • Humans
  • Indonesia / epidemiology
  • Japan / epidemiology
  • Male
  • Metaplasia
  • Middle Aged
  • Precancerous Conditions / ethnology*
  • Precancerous Conditions / microbiology
  • Precancerous Conditions / pathology
  • Prevalence
  • Severity of Illness Index
  • Stomach Neoplasms / ethnology*
  • Stomach Neoplasms / microbiology
  • Stomach Neoplasms / pathology
  • Urease / analysis
  • Young Adult

Substances

  • Urease