Controversies about occult hepatitis B virus infection

World J Gastroenterol. 2009 Oct 21;15(39):4986-7. doi: 10.3748/wjg.15.4986.


We read with great interest the paper written by Shi et al, reviewing the molecular characteristics and stages of chronic hepatitis B virus (HBV) infection. We think that some points in the definition of occult HBV infection (OBI) and their conclusion about the management of OBI may need further considerations.

Publication types

  • Comment
  • Letter

MeSH terms

  • Antiviral Agents / therapeutic use
  • DNA, Viral / blood*
  • Hepatitis B Antigens / blood
  • Hepatitis B virus* / genetics
  • Hepatitis B virus* / immunology
  • Hepatitis B, Chronic* / complications
  • Hepatitis B, Chronic* / diagnosis
  • Hepatitis B, Chronic* / drug therapy
  • Humans
  • Practice Guidelines as Topic
  • Viral Load
  • Virus Replication


  • Antiviral Agents
  • DNA, Viral
  • Hepatitis B Antigens