Inhibition of cell proliferation by the cholecystokinin antagonist L-364,718

Exp Cell Res. 1991 Jan;192(1):189-92. doi: 10.1016/0014-4827(91)90174-s.

Abstract

Specific cholecystokinin (CCK) receptor and gastrin receptor antagonists were used to assess what role, if any, these receptors have in autocrine cell growth. Although the cholecystokinin receptor antagonist, L-364,718, inhibited cell proliferation in a broad spectrum of cell lines, the gastrin antagonist, L-365,260, had no effect on cell proliferation. In addition neither added gastrin17, nor sulfated cholecystokinin8, could reverse the inhibitory action of L-364,718. It is proposed that L-364,718 inhibits cell proliferation independently of classical gastrin/CCK receptors.

MeSH terms

  • Benzodiazepinones / pharmacology*
  • Cell Division / drug effects*
  • Cell Line
  • Cholecystokinin / antagonists & inhibitors*
  • Colon / cytology
  • Colon / drug effects
  • DNA Replication / drug effects
  • Devazepide
  • Humans
  • Phenylurea Compounds*
  • Receptors, Cholecystokinin / antagonists & inhibitors
  • Tumor Cells, Cultured

Substances

  • Benzodiazepinones
  • Phenylurea Compounds
  • Receptors, Cholecystokinin
  • L 365260
  • Cholecystokinin
  • Devazepide