The role of mitochondrial dysfunction and drug safety

IDrugs. 2009 Nov;12(11):706-10.


Mitochondria are the energy powerhouses of cells and are essential for cell survival. Evidence demonstrates that mitochondria are the off-targets of many drugs belonging to a diverse array of classes. This feature review discusses the mechanisms by which drugs impair mitochondrial function, and describes some of the high-throughput methods being used to screen for drug-induced mitochondrial impairment.

Publication types

  • Review

MeSH terms

  • Animals
  • Drug Design
  • Drug-Related Side Effects and Adverse Reactions*
  • High-Throughput Screening Assays / methods
  • Humans
  • Mitochondria / drug effects*
  • Mitochondria / metabolism
  • Mitochondrial Diseases / chemically induced*
  • Toxicity Tests / methods