Management of hematological malignancies during pregnancy

Am J Hematol. 2009 Dec;84(12):830-41. doi: 10.1002/ajh.21547.

Abstract

The management of hematological malignancies during pregnancy is a challenging endeavor, which not only requires technical skills and knowledge by the clinicians but also requires sound clinical judgment and compassion, keeping in mind the patient and family preferences and, ultimately, the wellbeing of the neonate. The incidence of hematological malignancies during pregnancy is rare, ranging from 1 in 1,000 to 1 in 10,000 deliveries, impeding the design and execution of large prospective studies. The purpose of this review is to evaluate the limited existing data and make useful suggestions in the management of acute and chronic leukemias, Hodgkin and non-Hodgkin lymphomas, plasma cell myeloma, and other hematological malignancies, such as myelodysplastic syndromes and hairy cell leukemia, during pregnancy.

Publication types

  • Review

MeSH terms

  • Abnormalities, Drug-Induced / etiology
  • Abnormalities, Drug-Induced / prevention & control
  • Abortion, Induced
  • Adult
  • Antiemetics / therapeutic use
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / adverse effects
  • Antineoplastic Agents / therapeutic use
  • Cesarean Section
  • Clinical Protocols
  • Combined Modality Therapy
  • Contraindications
  • Disease Management
  • Female
  • Hematologic Neoplasms / drug therapy*
  • Hematologic Neoplasms / epidemiology
  • Hematologic Neoplasms / therapy
  • Humans
  • Incidence
  • Infant, Newborn
  • Infant, Newborn, Diseases / chemically induced
  • Infant, Newborn, Diseases / prevention & control
  • Leukapheresis
  • Pregnancy
  • Pregnancy Complications, Hematologic / drug therapy*
  • Pregnancy Complications, Hematologic / epidemiology
  • Pregnancy Complications, Hematologic / therapy
  • Pregnancy Complications, Neoplastic / drug therapy*
  • Pregnancy Complications, Neoplastic / epidemiology
  • Pregnancy Complications, Neoplastic / therapy
  • Pregnancy Outcome
  • Pregnancy Trimesters

Substances

  • Antiemetics
  • Antineoplastic Agents