Sister chromatid tension and the spindle assembly checkpoint

Curr Opin Cell Biol. 2009 Dec;21(6):785-95. doi: 10.1016/j.ceb.2009.09.007. Epub 2009 Oct 19.

Abstract

The spindle assembly checkpoint (SAC) is a feedback control system that monitors the state of kinetochore/microtubule attachment during mitosis and halts cell cycle progression until all chromosomes are properly aligned at the metaphase plate. The state of chromosome-microtubule attachment is implicated as a crucial factor in the checkpoint response. On the contrary, lack of tension in the centromere-kinetochore region of sister chromatids has been shown to regulate a pathway of correction of undesired chromosome-microtubule connections, while the presence of tension is believed to promote the stabilization of attachments. We discuss how tension-sensitive phenomena, such as attachment correction and stabilization, relate to the SAC and we speculate on the existence of a single pathway linking error correction and SAC activation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Aurora Kinases
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism
  • Chromatids / metabolism*
  • Chromosome Segregation / physiology
  • Humans
  • Kinetochores / metabolism
  • Microtubules
  • Mitosis
  • Models, Biological
  • Protein-Serine-Threonine Kinases / genetics
  • Protein-Serine-Threonine Kinases / metabolism
  • Spindle Apparatus / genetics
  • Spindle Apparatus / metabolism*

Substances

  • Cell Cycle Proteins
  • Aurora Kinases
  • Protein-Serine-Threonine Kinases